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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) greater than 27, given that they also are afflicted by weight-related medical issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder in addition to being an aid to quitting smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight management for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes indicated that patients had the average weight loss of four.1% instead of participants have been given placebos) after a 12- month period, while a different study involving patients with diabetes had the average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to lose weight naturally can be very effective there are combinations while watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you need to err assisting caution and allow the FDA do its job and demand some investigation be done in order that the public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say almost anything to keep people on his or her medications.

Researchers found that participants investing in this drug for any year, dropped excess weight within four weeks and have kept the body weight off through the entire 56 weeks with the study. Contrave can be a combination with the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them more effective and safer.

Combo-pilling is the newest fad or also the newest ahead under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular will be the fact that since right now there aren't any long term prescription weightloss pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure level and heartrate, and mustn't be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise hypertension and heart rate and must not be used in patients with uncontrolled high blood pressure, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients to the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.


The course of recovery, even for those taking the medications, centers more on talk and fewer on pills because while drugs like acamprosate and naltrexone help change brain chemistry, they don't really change minds. Once you're taking away the alcohol, sometimes with the successful utilization of prescribed medicine, the minds still need work. Alcoholics who slip in recovery and non-alcoholics drink for essentially the same reason: It relieves social/physical/emotional tension. With alcoholics however, their own health are programmed differently genetically and respond to drinking with additional drinking. So counseling or perhaps a 12-step meeting helps those abstinent keep from taking the first drink. Recovery has very little to do with stopping the drinking and the ones successful in recovery admit they're success is founded on learning or relearning the best way to manage life's tensions.